Radiation Tags - Differential Diagnosis of https://ddxof.com/tag/radiation/ A systematic approach to the evaluation and management of various complaints. Wed, 24 Jan 2018 21:51:17 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.1 https://ddxof.com/wp-content/uploads/2017/08/cropped-ddxof@1x-1-32x32.png Radiation Tags - Differential Diagnosis of https://ddxof.com/tag/radiation/ 32 32 46076767 Radiation Exposure https://ddxof.com/radiation-exposure/ Tue, 10 Jan 2017 08:00:54 +0000 http://ddxof.com/?p=1868 Physics Units Gray (amount of radiation absorbed by body) Sievert (toxicity associated with radiation exposure) Types Alpha: 0.1mm penetration, injury through ingestion Beta: 1cm penetration, injury through skin or ingestion Gamma: deep penetration Factors Time and distance (1/d2) Shielding Radiosensitive cells (rapidly dividing such as hematopoetic, GI) Injury Localized: epilation or burns, delayed by days... Continue reading →

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  • Units
    • Gray (amount of radiation absorbed by body)
    • Sievert (toxicity associated with radiation exposure)
  • Types
    • Alpha: 0.1mm penetration, injury through ingestion
    • Beta: 1cm penetration, injury through skin or ingestion
    • Gamma: deep penetration
  • Factors
    • Time and distance (1/d2)
    • Shielding
    • Radiosensitive cells (rapidly dividing such as hematopoetic, GI)

Injury

  • Localized: epilation or burns, delayed by days
  • Internal (inhaled, ingestion)
    • Radioactive iodine: high dose results in thyroid ablation, low dose increases risk of thyroid malignancy
  • External: managed by removing clothing, soap/water shower
  • Whole body (gamma)
System Dose Time of onset Signs/Symptoms
Hematopoetic 2G 2d Pancytopenia, increased risk of infection
GI 6G Hours Nausea/vomiting, diarrhea, GI bleeding
CV/CNS 10G Minutes Shock, seizure

Key clinical features

  • Multiple affected individuals with nausea/vomiting suggests radiation exposure
  • Rapidity of onset of symptoms suggests increased dose/exposure
  • LD505G
  • Prognosis by lymphocyte count
    • ALC >1000 at 48h suggests good prognosis
    • ALC <300 at 48h suggests poor prognosis

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